RCT 2012

Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01% doses (Atropine for the Treatment of Myopia 2)

Audrey Chia; Wei-Han Chua; Yin-Bun Cheung; Wan-Ling Wong; Anushia Lingham; Allan Fong; Donald Tan

Ophthalmology

What does this source bring?

ATOM2 compared the atropine concentrations of 0,5%, 0,1% and 0,01%; lower concentrations had a milder visual symptom profile.

No parallel placebo arm. The historical placebo with ATOM1 is not an equivalent random comparator.

CLAIM-ATOM2

Scope of testing and verification

The role of the record
Source of the claim
Population
Children 6–12 years old, Singapore
N
400
Geography
Singapore
Observation (months)
24
Comparator
Three concentrations of atropine
Result
ATOM2 compared the atropine concentrations of 0,5%, 0,1% and 0,01%; lower concentrations had a milder visual symptom profile.
Safety
This record does not allow estimation of the frequency of rare adverse events.
Device/structure
Not applicable / not determined within the verified range
Publisher of the publication
Elsevier BV
Financing
Not determined within the proven range; see the declaration in full text.
Conflicts of interest
Not determined within the proven range. The absence of confirmation does not mean the absence of conflict.
DOI
10.1016 /j.ophtha. 2011.07.031
PMID
21963266
What was checked
Bibliographic metadata and abstract in Europe PMC / PubMed; Crossref metadata
Date of verification
2026-09-09

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